Evolutionary Biology

“Diversity and molecular evolution of pathogen populations” (PTDC/BIA-BDE/65276/2006) financed by FCT.

“Rates of mutations in the protozoa Tetrahymena thermophila” (PTDC/BIA-BDE/73163/2006) financed by FCT.

"Population Genetics of Adaptation in E. coli". Project started in July 2003 and financed by FCT/FEDER (POCTI/BSE/46856/2002).

Epidemiology and Evolution of Infecious Diseases: Influenza A and Malaria. Project started in June 2003 and financed for three years by FCT (POCTI/MAT/47510/2002).

The role of the social interaction in bacterial diversity and evolution. Started in January 2005, financed by FCT (POCTI/BIA-BDE/55758/2004)

Perfeito L, Sousa A. Gordo I (2011) Fitness effects of mutations in bacteria Journal of Molecular Microbiology and Biotechnology.

Silva RF, Mendonça SCM, Carvalho LM, Reis AM, Gordo I, et al. (2011) Pervasive Sign Epistasis between Conjugative Plasmids and Drug-Resistance Chromosomal Mutations. PLoS Genet 7(7): e1002181. doi:10.1371/journal.pgen.1002181

Brito P, E. Guilherme, H. Soares and I. Gordo (2010) Mutation accumulation in Tetrahymena, BMC Evolutionary Biology

Trindade S., Perfeito L. and I. Gordo (2010) Rate and effects of spontaneous mutations that affect fitness in mutator Escherichia coli. Philosophical Transactions B.

Marais G, P. Campos and I. Gordo (2010) Genome Biology and Evolution

Trindade S, Sousa A, Xavier KB, Dionisio F,Ferreira MG and I.Gordo (2009) Positive Epistasis Drives the Acquisition of Multidrug Resistance PloS Genetics 5(7): e1000578

A. Sousa and I. Gordo Mutation, selection and epistasis in bacteria (2009), Enc. of Life Sciences

Charlesworth B., Betancourt A.J., Kaiser V.B. and I. Gordo (2009) Genetic Recombination and Molecular Evolution Cold Spring Harb Symp Quant Biol, doi: 10.1101/sqb.2009.74.015

Gordo I., Gomes MGM, Reis, DG and PRA. Campos (2009) Genetic diversity in the SIR model of pathogen evolution PloS One 4(3): e4876.

Campos PRA, Neto PSCA, de Oliveira VM and I. Gordo (2008) Environmental heterogeneity enhances clonal interference Evolution 62 (6): 1390-1399

Perfeito L, L. Fernandes, C. Mota and I. Gordo (2007) Adaptive Mutations in Bacteria: High Rate and Small Effects. Science 317(5839):813-5. [ Abstract ] [ FullText]

Gordo I. and PRA Campos (2007) Patterns of genetic variation in populations of infectious agents. BMC Evol Biol. 7(1):116 (pdf)

Combadão J , Dionisio F., Campos. PRA and I. Gordo (2007) Small-word networks decrease the speed of Muller's ratchet Genetical Research 89(1):7-18 [Request Reprint].

Gokaydin D, Oliveira-Martins JB , Gordo I, and MGM Gomes (2007) The reinfection threshold regulates pathogen diversity: the case of influenza. J Roy. Soc. Interface 4(12):137-42. (pdf)

Campos PRA and I. Gordo (2006) Pathogen genetic variation in small-world host contact structures. J. Stat. Mechanics L12003(preprint)

Campos PRA, Combadão J , Dionisio F. and I. Gordo (2006) Muller's ratchet in random graphs and scale free networks Phys. Rev. E 74, 042901(pdf)

Dionisio, F. and I. Gordo (2007) Controlling excludability in the evolution of cooperation. Evolutionary Ecology Research 9(2): 365-373 (pdf)

Faro J, Combadão J and I.Gordo (2006) Did Germinal Centers evolve under differential effects of diversity vs affinity? Lecture Notes in Computer Science 4163: 1-8

Perfeito L, I. Gordo and PRA Campos (2006) The effect of spatial structure in adaptive evolution. European Physical Journal B, in press.(pdf)

Gordo, I. and P.R.A. Campos (2006). Adaptive evolution in a spatially structured asexual population Genetica (pdf)

Dionisio, F., Gordo, I. (2006) The Tragedy of the Commons, the Public Goods Dilemma, and the meaning of Rivalry and Excludability in Evolutionary Biology. Evolutionary Ecology Research 8: 321-332 [Pdf]

Dionisio, F., I. C. Conceição, A. C. R. Marques, L. Fernandes and I. Gordo (2005) The evolution of a conjugative plasmid and its ability to increase bacterial fitness. Biol. Letters [Pdf]

Gordo, I. and F. Dionisio (2005) A non-equilibrium model for estimating the parameters of deleterious mutations. Phys. Rev. E 71, 031907 [Pdf]

Rosas, A., I.Gordo and P.R.A. Campos (2005) Scaling, genetic drift and clonal interference in the extinction pattern of asexual populations. Phys.Rev. E 72, 012901 [Request Reprint]

Bachtrog, D. and I. Gordo (2004) Adaptation of asexual populations under Muller’s ratchet. Evolution 58(7) 1403-13. [Full text][Request Reprint]

Gordo, I., A. Navarro and B. Charlesworth (2002) Muller's ratchet and the pattern of variation at a neutral locus. Genetics 161: 835-848 [Abstract] [Full text] [pdf]

Gordo, I. and B. Charlesworth (2001) Genetic linkage and molecular evolution. Current Biology 11:R684-6.[ Abstract ] [ FullText] [Pdf] [Request Reprint]

Gordo, I. and B. Charlesworth (2001) The speed of Muller's ratchet with background selection, and the degeneration of Y chromosomes. Genetical Research 78:149-61[ Abstract] [pdf]

Gordo, I. and B. Charlesworth (2000) On the speed of Muller's ratchet. Genetics 156: 2137-40 [ FullText ][pdf]

Gordo, I. and B. Charlesworth (2000) The degeneration of asexual haploid populations and the speed of Muller's ratchet. Genetics 154: 1379-87[ FullText ][pdf ]

	Isabel Gordo Main scientific area of research: Evolutionary Biology and Population Genetics.
	Present position: Principal Investigator at Instituto Gulbenkian de Ciência, Evolutionary Biology Group, Estudos Avançados Academic degrees: PhD, Biology - Population Genetics, University of Edinburgh , UK, 2001. Degree in Physics, Instituto Superior Técnico , Lisboa, Portugal, 1997. Research interests: In general, the area of research that I am interested is Evolutionary Biology. I am interested in combining both theoretical and empirical work with the aim at understanding the major forces that shape variation in natural populations. I am using E. coli as a model organism to test theoretical predictions about the evolution of mutation rates and the genetics of adaptation. Other topics of current work are: evolution of antibiotic resistance and antigenic diversity in pathogens, and chromosomal speciation. Research Projects: As Principal Investigator: “Adaptation within ecosystems”, ERC grant 2010-2015. “Epistasis and antibiotic resistance”, 2011-2014 financed by FCT. “Diversity and molecular evolution of pathogen populations” (PTDC/BIA-BDE/65276/2006) financed by FCT. “Rates of mutations in the protozoa Tetrahymena thermophila” (PTDC/BIA-BDE/73163/2006) financed by FCT. "Population Genetics of Adaptation in E. coli". Project started in July 2003 and financed by FCT/FEDER (POCTI/BSE/46856/2002). As Colaborator: Epidemiology and Evolution of Infecious Diseases: Influenza A and Malaria. Project started in June 2003 and financed for three years by FCT (POCTI/MAT/47510/2002). The role of the social interaction in bacterial diversity and evolution. Started in January 2005, financed by FCT (POCTI/BIA-BDE/55758/2004) Publications: Perfeito L, Sousa A. Gordo I (2011) Fitness effects of mutations in bacteria Journal of Molecular Microbiology and Biotechnology. Silva RF, Mendonça SCM, Carvalho LM, Reis AM, Gordo I, et al. (2011) Pervasive Sign Epistasis between Conjugative Plasmids and Drug-Resistance Chromosomal Mutations. PLoS Genet 7(7): e1002181. doi:10.1371/journal.pgen.1002181 Brito P, E. Guilherme, H. Soares and I. Gordo (2010) Mutation accumulation in Tetrahymena, BMC Evolutionary Biology Trindade S., Perfeito L. and I. Gordo (2010) Rate and effects of spontaneous mutations that affect fitness in mutator Escherichia coli. Philosophical Transactions B. Marais G, P. Campos and I. Gordo (2010) Genome Biology and Evolution Trindade S, Sousa A, Xavier KB, Dionisio F,Ferreira MG and I.Gordo (2009) Positive Epistasis Drives the Acquisition of Multidrug Resistance PloS Genetics 5(7): e1000578 A. Sousa and I. Gordo Mutation, selection and epistasis in bacteria (2009), Enc. of Life Sciences Charlesworth B., Betancourt A.J., Kaiser V.B. and I. Gordo (2009) Genetic Recombination and Molecular Evolution Cold Spring Harb Symp Quant Biol, doi: 10.1101/sqb.2009.74.015 Gordo I., Gomes MGM, Reis, DG and PRA. Campos (2009) Genetic diversity in the SIR model of pathogen evolution PloS One 4(3): e4876. Campos PRA, Neto PSCA, de Oliveira VM and I. Gordo (2008) Environmental heterogeneity enhances clonal interference Evolution 62 (6): 1390-1399 Perfeito L, L. Fernandes, C. Mota and I. Gordo (2007) Adaptive Mutations in Bacteria: High Rate and Small Effects. Science 317(5839):813-5. [ Abstract ] [ FullText] Gordo I. and PRA Campos (2007) Patterns of genetic variation in populations of infectious agents. BMC Evol Biol. 7(1):116 (pdf) Combadão J , Dionisio F., Campos. PRA and I. Gordo (2007) Small-word networks decrease the speed of Muller's ratchet Genetical Research 89(1):7-18 [Request Reprint]. Gokaydin D, Oliveira-Martins JB , Gordo I, and MGM Gomes (2007) The reinfection threshold regulates pathogen diversity: the case of influenza. J Roy. Soc. Interface 4(12):137-42. (pdf) Campos PRA and I. Gordo (2006) Pathogen genetic variation in small-world host contact structures. J. Stat. Mechanics L12003(preprint) Campos PRA, Combadão J , Dionisio F. and I. Gordo (2006) Muller's ratchet in random graphs and scale free networks Phys. Rev. E 74, 042901(pdf) Dionisio, F. and I. Gordo (2007) Controlling excludability in the evolution of cooperation. Evolutionary Ecology Research 9(2): 365-373 (pdf) Faro J, Combadão J and I.Gordo (2006) Did Germinal Centers evolve under differential effects of diversity vs affinity? Lecture Notes in Computer Science 4163: 1-8 Perfeito L, I. Gordo and PRA Campos (2006) The effect of spatial structure in adaptive evolution. European Physical Journal B, in press.(pdf) Gordo, I. and P.R.A. Campos (2006). Adaptive evolution in a spatially structured asexual population Genetica (pdf) Dionisio, F., Gordo, I. (2006) The Tragedy of the Commons, the Public Goods Dilemma, and the meaning of Rivalry and Excludability in Evolutionary Biology. Evolutionary Ecology Research 8: 321-332 [Pdf] Dionisio, F., I. C. Conceição, A. C. R. Marques, L. Fernandes and I. Gordo (2005) The evolution of a conjugative plasmid and its ability to increase bacterial fitness. Biol. Letters [Pdf] Gordo, I. and F. Dionisio (2005) A non-equilibrium model for estimating the parameters of deleterious mutations. Phys. Rev. E 71, 031907 [Pdf] Rosas, A., I.Gordo and P.R.A. Campos (2005) Scaling, genetic drift and clonal interference in the extinction pattern of asexual populations. Phys.Rev. E 72, 012901 [Request Reprint] Bachtrog, D. and I. Gordo (2004) Adaptation of asexual populations under Muller’s ratchet. Evolution 58(7) 1403-13. [Full text][Request Reprint] Gordo, I., A. Navarro and B. Charlesworth (2002) Muller's ratchet and the pattern of variation at a neutral locus. Genetics 161: 835-848 [Abstract] [Full text] [pdf] Gordo, I. and B. Charlesworth (2001) Genetic linkage and molecular evolution. Current Biology 11:R684-6.[ Abstract ] [ FullText] [Pdf] [Request Reprint] Gordo, I. and B. Charlesworth (2001) The speed of Muller's ratchet with background selection, and the degeneration of Y chromosomes. Genetical Research 78:149-61[ Abstract] [pdf] Gordo, I. and B. Charlesworth (2000) On the speed of Muller's ratchet. Genetics 156: 2137-40 [ FullText ][pdf] Gordo, I. and B. Charlesworth (2000) The degeneration of asexual haploid populations and the speed of Muller's ratchet. Genetics 154: 1379-87[ FullText ][pdf ]