E-mail: rramiro at igc.gulbenkian.pt
I am currently a post-doc in the Evolutionary Biology Group. I graduated in Biology in 2007 (Universidade Lusófona de Humanidades e Tecnologias, Lisbon), after which, I went on to do a PhD at the University of Edinburgh (2012).
I am generally interested on the evolutionary ecology of host-microbe interactions. During my PhD, I worked in Sarah Reece‘s lab to study how malaria parasites (Plasmodium) interact with their environment and how these interactions shape several traits, with a focus on traits involved in transmission.
Since joining the Evolutionary biology lab, I have been involved in understanding the processes of adaptation of Escherichia coli to macrophages and to the mouse gut. Currently, I am focusing on studying the long-term adaptation of E. coli to the mouse gut and the dynamics of the evolutionary process.
Sousa A, Ramiro RS, Barroso-Batista J, Güleresi D, Lourenço M, Gordo I (2017) Recurrent Reverse Evolution Maintains Polymorphism After Strong Bottlenecks in Commensal Gut Bacteria. Molecular Biology and Evolution 34(11):2879-2892. doi: 10.1093/molbev/msx221
Lourenço M, Ramiro RS, Güleresi D, Barroso-Batista J, Xavier KB, Gordo I, et al. (2016) A Mutational Hotspot and Strong Selection Contribute to the Order of Mutations Selected for during Escherichia coli Adaptation to the Gut. PLoS Genet 12(11): e1006420. doi:10.1371/journal.pgen.1006420
Ramiro, R. S., Costa, H. and Gordo, I. (2016), Macrophage adaptation leads to parallel evolution of genetically diverse Escherichia coli small-colony variants with increased fitness in vivo and antibiotic collateral sensitivity. Evol Appl, 9: 994–1004. doi:10.1111/eva.12397 medi
Miskinyte, M., Sousa, A., Ramiro, R.S., de Sousa, J.A.M., Kotlinowski, J., Caramalho, I, Magalhães, S., Soares, M.P. & Gordo, I. (2013) The Genetic Basis of Escherichia coli Pathoadaptation to Macrophages. PLoS Pathog. 9(12): e1003802. (doi:10.1371/journal.ppat.1003802)
Ramiro, R. S., J. Alpedrinha, L. Carter, A. Gardner, and S. E. Reece. 2011. Sex and Death The Effects of Innate Immune Factors on the Sexual Reproduction of Malaria Parasites. Plos Pathogens 7(3): e1001309