Ricardo Ramiro

E-mail: rramiro at igc.gulbenkian.pt

Short Bio.

I am currently a post-doc in the Evolutionary Biology Group. I graduated in Biology in 2007 (Universidade Lusófona de Humanidades e Tecnologias, Lisbon), after which, I went on to do a PhD at the University of Edinburgh (2012).

Research Interests

I am generally interested on the evolutionary ecology of host-microbe interactions. During my PhD, I worked in Sarah Reece‘s lab to study how malaria parasites (Plasmodium) interact with their environment and how these interactions shape several traits, with a focus on traits involved in transmission.

Since joining the Evolutionary biology lab, I have been involved in understanding the processes of adaptation of Escherichia coli to macrophages and to the mouse gut. Currently, I am focusing on studying the long-term adaptation of E. coli to the mouse gut and the dynamics of the evolutionary process.


Sousa A, Ramiro RS, Barroso-Batista J, Güleresi D, Lourenço M, Gordo I (2017) Recurrent Reverse Evolution Maintains Polymorphism After Strong Bottlenecks in Commensal Gut Bacteria. Molecular Biology and Evolution 34(11):2879-2892. doi: 10.1093/molbev/msx221

Sousa A, Frazão N, Ramiro RS, Gordo I (2017) Evolution of commensal bacteria in the intestinal tract of mice. Current Opinion in Microbiology 38:114-121. http://dx.doi.org/10.1016/j.mib.2017.05.007

Lourenço M, Ramiro RS, Güleresi D, Barroso-Batista J, Xavier KB, Gordo I, et al. (2016) A Mutational Hotspot and Strong Selection Contribute to the Order of Mutations Selected for during Escherichia coli Adaptation to the Gut. PLoS Genet 12(11): e1006420. doi:10.1371/journal.pgen.1006420

Ramiro, R. S., Costa, H. and Gordo, I. (2016), Macrophage adaptation leads to parallel evolution of genetically diverse Escherichia coli small-colony variants with increased fitness in vivo and antibiotic collateral sensitivity. Evol Appl, 9: 994–1004. doi:10.1111/eva.12397 medi

Ramiro, R. S., Pollitt, L. C., Mideo, N., & Reece, S. E. (2016). Facilitation through altered resource availability in a mixed species rodent malaria infection. Ecology Letters, 19(9), 1041-1050.

Ramiro, R. S., Khan, S. M., Franke-Fayard, B., Janse, C. J., Obbard, D. J., & Reece, S. E. (2015). Hybridization and pre-zygotic reproductive barriers in Plasmodium. Proc. R. Soc. B, 282 (1806)

Miskinyte, M., Sousa, A., Ramiro, R.S., de Sousa, J.A.M., Kotlinowski, J., Caramalho, I, Magalhães, S., Soares, M.P. & Gordo, I. (2013) The Genetic Basis of Escherichia coli Pathoadaptation to Macrophages. PLoS Pathog. 9(12): e1003802. (doi:10.1371/journal.ppat.1003802)

Ramiro, R. S., S. E. Reece, and D. J. Obbard. 2012. Molecular evolution and phylogenetics of rodent malaria parasites. BMC Evolutionary Biology 12:219.

Ramiro, R. S., J. Alpedrinha, L. Carter, A. Gardner, and S. E. Reece. 2011. Sex and Death The Effects of Innate Immune Factors on the Sexual Reproduction of Malaria Parasites. Plos Pathogens 7(3): e1001309

Reece, S. E., R. S. Ramiro, and D. H. Nussey. 2009. Plastic parasites: sophisticated strategies for survival and reproduction? Evolutionary Applications 2:11–23.